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CHAPTER 13 Antimicrobials-Fighting Infection 213 Extended-spectrum Penicillin Pregnancy Category: B Route Dose Time carbenicillin (Geocillin) Protein-Binding: 50 Half-Life: 1112 hours PO 0.
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In contrast, only Nick C showed an enhanced binding affinity, indicating that the increased flexibility of the Nick A substrate is fortuitously compensated elsewhere in the bent complex in such a way as to accelerate the unbendingdissociation rate by roughly the same factor.
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